細(xì)胞膜標(biāo)志物
細(xì)胞膜是細(xì)胞的外部結(jié)構(gòu)，是防止細(xì)胞外物質(zhì)自由進(jìn)入細(xì)胞的屏障，它不僅為細(xì)胞提供物理保護(hù)，還負(fù)責(zé)控制物質(zhì)的進(jìn)出、細(xì)胞間通訊以及許多其他重要功能。細(xì)胞膜主要由磷脂雙分子層構(gòu)成，其中包含蛋白質(zhì)、膽固醇和糖分子。磷脂雙分子層由兩個(gè)磷脂分子層組成，疏水性的脂肪酸尾部朝內(nèi)，親水性的頭部朝外形成一個(gè)半透膜。
細(xì)胞間黏附分子（Cell Adhesion Molecules,CAMs）、受體酪氨酸激酶（Receptor Tyrosine Kinases,RTKs）和離子通道蛋白等細(xì)胞膜標(biāo)志物在細(xì)胞功能和信號(hào)轉(zhuǎn)導(dǎo)中起關(guān)鍵作用。CAMs是一類膜蛋白，具有細(xì)胞黏附、細(xì)胞間通信和信號(hào)傳導(dǎo)的功能。RTKs是一類跨膜受體蛋白，能夠通過(guò)受體激酶活化細(xì)胞內(nèi)的信號(hào)通路。常見的RTKs包括表皮生長(zhǎng)因子受體（EGFR）、血小板源性生長(zhǎng)因子受體（PDGFR）和神經(jīng)生長(zhǎng)因子受體（NGFR）等。離子通道蛋白是一類位于細(xì)胞膜上的蛋白質(zhì)，它們形成了穿越細(xì)胞膜的通道，能夠調(diào)節(jié)細(xì)胞內(nèi)外離子的平衡。常見的離子通道蛋白包括鈉、鉀和鈣通道等，它們對(duì)于維持細(xì)胞的電生理特性和信號(hào)轉(zhuǎn)導(dǎo)至關(guān)重要，并且參與神經(jīng)傳導(dǎo)、肌肉收縮和心臟節(jié)律等生理過(guò)程。
ATP1A1編碼的蛋白屬于p型陽(yáng)離子轉(zhuǎn)運(yùn)ATP酶家族和Na+/K+ - ATP酶亞家族。ATP1A1是活性酶的催化成分，可催化ATP的水解，并通過(guò)質(zhì)膜交換鈉離子和鉀離子。這一作用產(chǎn)生了鈉離子和鉀離子的電化學(xué)梯度，為各種營(yíng)養(yǎng)物質(zhì)的主動(dòng)運(yùn)輸提供能量。
圖1 ATP1A1抗體免疫組化結(jié)果示意圖
（商品貨號(hào)：K111558P）
CDH3基因位于16號(hào)染色體長(zhǎng)臂區(qū)域的一個(gè)基因簇中，編碼鈣粘蛋白超家族中的一種經(jīng)典鈣粘蛋白。鈣粘蛋白是一種依賴鈣的細(xì)胞粘附蛋白，它們?cè)谶B接細(xì)胞時(shí)優(yōu)先以親同性的方式相互作用，鈣粘蛋白可能有助于異質(zhì)細(xì)胞類型的分選。
圖3 CDH3抗體免疫組化結(jié)果示意圖
（商品貨號(hào)：K111121P）
已有一些蛋白被鑒定可用作細(xì)胞膜標(biāo)志物（見表1）。
表 1 細(xì)胞膜標(biāo)志物
相關(guān)產(chǎn)品
|
產(chǎn)品貨號(hào) |
產(chǎn)品名稱 |
|
K109982P |
Anti-ATP1A1 Polyclonal Antibody |
|
K110469P |
Anti-ATP1A1 Polyclonal Antibody |
|
K111558P |
Anti-ATP1A1 Polyclonal Antibody |
|
K005524P |
Anti-ATP1A1 Polyclonal Antibody |
|
K007644P |
Anti-ATP1A1 Polyclonal Antibody |
|
K111556P |
Anti-ATP1A2 Polyclonal Antibody |
|
K004215P |
Anti-ATP1B1 Polyclonal Antibody |
|
K106561P |
Anti-CADH1 Polyclonal Antibody |
|
K010592M |
Anti-CD26(APC) Monoclonal Antibody |
|
K010787M |
Anti-CD26(FITC) Monoclonal Antibody |
|
K011048M |
Anti-CD26(PE) Monoclonal Antibody |
|
K115158P |
Anti-CDH1 Polyclonal Antibody |
|
K002267P |
Anti-CDH1 Polyclonal Antibody |
|
K111121P |
Anti-CDH3 Polyclonal Antibody |
|
K008218P |
Anti-CDH3 Polyclonal Antibody |
|
K111282P |
Anti-CDH5 Polyclonal Antibody |
|
K001742P |
Anti-CDH5 Polyclonal Antibody |
|
K106786P |
Anti-DPP4 Polyclonal Antibody |
|
K002791P |
Anti-DPP4 Polyclonal Antibody |
|
K011355P |
Anti-E-Cadherin Polyclonal Antibody |
|
K000137M |
Anti-EGFR Monoclonal Antibody |
|
K000139M |
Anti-EGFR Monoclonal Antibody |
|
K000140M |
Anti-EGFR Monoclonal Antibody |
|
K106563P |
Anti-EGFR Polyclonal Antibody |
|
K112830P |
Anti-EGFR Polyclonal Antibody |
|
K112831P |
Anti-EGFR Polyclonal Antibody |
|
K002208P |
Anti-EGFR Polyclonal Antibody |
|
K002209P |
Anti-EGFR Polyclonal Antibody |
|
K002298P |
Anti-EGFR Polyclonal Antibody |
|
K002300P |
Anti-EGFR Polyclonal Antibody |
|
K009458P |
Anti-EGFR Polyclonal Antibody |
|
K009564P |
Anti-EGFRvII Polyclonal Antibody |
|
K009589P |
Anti-phospho-CTNNB1(Ser33+37) Polyclonal Antibody |
|
K006171P |
Anti-Phospho-EGFR-T669 Polyclonal Antibody |
|
K006212P |
Anti-Phospho-EGFR-Y1068 Polyclonal Antibody |
|
K006173P |
Anti-Phospho-EGFR-Y1148 Polyclonal Antibody |
|
K006169P |
Anti-Phospho-EGFR-Y845 Polyclonal Antibody |
|
K006172P |
Anti-Phospho-EGFR-Y992 Polyclonal Antibody |
|
K006172P |
Anti-Phospho-EGFR-Y992 Polyclonal Antibody |
