| 英文名稱 | Mouse hnRNP U Monoclonal Antibody |
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| 應(yīng)用2 | WB |
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| 克隆類型2 | Monoclonal Antibody |
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| 別名 | hnRNP U |
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| 應(yīng)用 | WB |
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| 稀釋比例 | WB1:1000 |
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| 交叉反應(yīng) | Human |
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| 蛋白分子量 | 110kDa |
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| Gene ID | 3192 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 儲存液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 70% Glycerol. |
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| 純化方法 | Affinity purification |
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| 亞型 | IgG1 |
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| 免疫原 | Purified recombinant human hnRNP U protein fragments expressed in E.coli. |
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| 性狀 | Lyophilized or Liquid |
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| Swiss Prot | Q00839 |
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| 克隆號 | 1B11-H2-B7 |
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| 克隆類型 | Monoclonal Antibody |
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| 來源 | Mouse |
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| 背景資料 | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008] |
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