| 英文名稱 | Rabbit CASP12 Polyclonal Antibody |
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| 應(yīng)用2 | WB IHC |
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| 克隆類型2 | Polyclonal Antibody |
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| 別名 | CASP-12;CASP12P1
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| 應(yīng)用 | WB,IHC |
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| 稀釋比例 | WB1:500-1:2000 IHC1:50-1:200 |
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| 交叉反應(yīng) | Human Mouse |
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| 蛋白分子量 | 39kDa |
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| Gene ID | 100506742 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 儲(chǔ)存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 純化方法 | Affinity purification |
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| 亞型 | IgG |
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| 免疫原 | A synthetic peptide of human CASP12 |
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| 性狀 | Lyophilized or Liquid |
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| Swiss Prot | Q6UXS9 |
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| 克隆類型 | Polyclonal Antibody |
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| 來源 | Rabbit |
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| 背景資料 | Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
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