| 英文名稱(chēng) | Rabbit CDK4 Polyclonal Antibody |
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| 應(yīng)用2 | WB IHC IF |
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| 克隆類(lèi)型2 | Polyclonal Antibody |
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| 別名 | CMM3;PSK-J3
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| 應(yīng)用 | WB,IHC,IF |
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| 稀釋比例 | WB1:500-1:2000 IHC1:50-1:200 IF1:20-1:100 |
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| 交叉反應(yīng) | Human Mouse Rat |
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| 蛋白分子量 | 34kDa |
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| Gene ID | 1019 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 儲(chǔ)存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 純化方法 | Affinity purification |
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| 亞型 | IgG |
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| 免疫原 | Recombinant protein of human CDK4 |
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| 性狀 | Lyophilized or Liquid |
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| Swiss Prot | P11802 |
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| 克隆類(lèi)型 | Polyclonal Antibody |
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| 來(lái)源 | Rabbit |
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| 背景資料 | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. |
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