| 英文名稱(chēng) | Rabbit NUP98 Polyclonal Antibody |
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| 應(yīng)用2 | WB |
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| 克隆類(lèi)型2 | Polyclonal Antibody |
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| 別名 | ADIR2;NUP196;NUP96
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| 應(yīng)用 | WB |
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| 稀釋比例 | WB1:1000-1:2000 |
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| 交叉反應(yīng) | Human Mouse |
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| 蛋白分子量 | 198kDa |
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| Gene ID | 4928 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 儲(chǔ)存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 純化方法 | Affinity purification |
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| 亞型 | IgG |
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| 免疫原 | Recombinant protein of human NUP98 |
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| 性狀 | Lyophilized or Liquid |
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| Swiss Prot | P52948 |
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| 克隆類(lèi)型 | Polyclonal Antibody |
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| 來(lái)源 | Rabbit |
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| 背景資料 | Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. |
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