| 英文名稱 | Rabbit DYRK1A Polyclonal Antibody |
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| 別名 | DYRK;DYRK1;HP86;MNB;MNBH;MRD7
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| 應(yīng)用 | WB |
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| 稀釋比例 | WB1:500-1:1000 |
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| 交叉反應(yīng) | Human Mouse Rat |
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| 蛋白分子量 | 86kDa |
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| Gene ID | 1859 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
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| 儲存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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| 純化方法 | Affinity purification |
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| 亞型 | IgG |
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| 免疫原 | Recombinant protein of human DYRK1A |
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| 性狀 | Lyophilized or Liquid |
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| Swiss Prot | Q13627 |
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| 克隆類型 | Polyclonal Antibody |
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| 來源 | Rabbit |
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| 背景資料 | This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. |
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